The incidence of congenital heart disease is 2-10 cases per 1000 live births. Management of CHD emphasize early complete repair before the heart adapt to the abnormal physiology. Nevertheless despite improve surgical technique, children still succumbs to post-operative multiple organ failure with significant impact on short-long term outcome. Improve of outcome of surgery requires identify patients vulnerable to organ failure, modifying perioperative risk factors and other effective intervention for organ preservation during surgery.