Mesotherapy used involves numerous, localized, intradermal orsubcutaneous injections containing combinations of vasodilators, antiinflammatorymedications, herbs, hormones, antibiotics, enzymes or coenzymes.The true mechanism of mesotherapy remains unknown. In theprevious decades, mesotherapy has been traditionally used for treatmentof musculoskeletal pain, lymphoedema and dental pain. However,nowadays; mesotherapy is primarily indicated for cosmetic proceduressuch as scarring, alopecia, photoaging, reduction of fat and cellulite, bodycontouring as well as facial skin rejuvenation. Several side effectsaccompanying mesotherapy technique and materials have been reported,so mesotherapy has become controversial as it is popular.