This is a retrospective study of the record of 80 cancer patients at pediatric age group who presented to Children Cancer Hospital Egypt in the period from July 2007 to March 2009.All patients had various types of malignancy and received various chemotherapy protocols .This study included risk factors of cardiotoxicity which are age, sex, cumulative dose of anthracyclines, type of malignancy, mediastinal irradiation, concomitant chemotherapy and underlying cardiac lesions.