Background: Psoriasis is a chronic inflammatory disease of the skin characterized by: an accelerated rate of keratinocyte proliferation, abnormal differentiation of epidermal keratinocytes, alteration in dermal angiogenesis and increased production of proinflammatory cytokines. Activation of LXRs stimulates keratinocyte differentiation, has an antiproliferative effect on keratinocyte and has an inhibitory effect on epidermal and TH 1 cytokines.Aim: To detect if there is a change in the expression of LXRs α and β in psoriatic skin or not, and if this change (if present) is related to severity of psoriasis or not.Patients and methods: Twenty five patients with psoriasis vulgaris and twenty five healthy volunteers served as controls were included in this study. Punch skin biopsies from sun protected areas were taken from lesional skin of the patients as well as from the normal skin of the control group and sent for quantitative PCR examination of LXR α and β mRNA.Results: The mean values of LXR α and β in the lesional skin of psoriatic patients were significantly lower than that in the control group (P Values for both LXR α and β were < 0.001). Correlating levels of LXR α and LXR β in the lesional skin of psoriatic patients of the studied cases to their PASI score showed a statistically significant inverse correlation.Conclusion: The study showed that LXRs may play a role in the pathogenesis of psoriasis. Further studies are also recommended to evaluate LXR agonist as a new therapy.