43637

Diagnosis of minimal hepatic encephalopathy using clinical and neurological study

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Internal Medicine

Advisors

El-Garem, Nuaman , Husain, Ayat-Allah F. , Sedrak, Heba K.

Authors

Shahin, Awattef Abdel-Muqtader Sayed Ahmad

Accessioned

2017-07-12 06:42:08

Available

2017-07-12 06:42:08

type

M.Sc. Thesis

Abstract

Background: The prevalence of minimal hepatic encephalopathy (MHE) varies according to the diagnostic tool used in its detection. Many studies tested psychometric, neurophysiological tests and computerized tests however a standardized approach to the diagnosis of MHE is not yet available. Aim of the study: Detection of the prevalence of MHE in our cirrhotic patients using modified mini-mental state examination (3MS), electroencephalogram (EEG), and critical flicker frequency. Patients and methods: the study included 60 patients divided into two groups: Group 1(40) patients with liver cirrhosis. Group 2(control) included twenty (20) healthy aged –matched controls. Patients are classified according to Child-Pugh grading. For all participants, (3MS), electroencephalogram (EEG), and critical flicker frequency were performed. Results: prevalence of MHE was high in patients compared to controls. 3MS detected lower score than controls in 35% of patients. EEG showed higher percentage of abnormalities; conventional EEG in 50% of patients was slow. Spectral EEG detected abnormalities in 90% of patients. On adding 3MS and sEEG, 92.9% of patients were abnormal. CFF showed similar results in patients compared to the control, detecting no abnormality. Conclusion: sEEG appears to be convenient tool to assess early stages in Hepatic encephalopathy (HE) in stable patients screened for cognitive function by 3MS. CFF was found to provide little, if any, information in routine search for MHE, provided sEEG and proper psychometric investigation are performed.

Issued

1 Jan 2010

DOI

http://dx.doi.org/10.21473/iknito-space/37574

Details

Type

Thesis

Created At

28 Jan 2023