The physiological role and pathophysiologic importance of resistin in humans are unclear. It was firstly proposed to be involved in insulin resistance and type 2 diabetes. Resistin was found to interact with and reinforce inflammatory pathways. C-reactive protein, a marker of inflammation, was reported to be positively correlated with resistin levels in several pathophysiological conditions. Recently, it is speculated that inflammatory, metabolic, and vascular abnormalities associated with increased circulating resistin levels may have a pathogenic role in chronic kidney disease.