HSCT and MSCT offer hope for a new effective treatment for MS. Recent trials of low intensity HSCT indicate that as researchers improve the conditioning protocol, they can significantly reduce the adverse side effects without decreasing efficacy. Similarly, a recent clinical trial evaluating MSCT concluded it was a feasible and safe treatment method for MS patients. Given MSCT’s positive potential on neural restoration and immunomodulation demonstrated in animal models, MSCT offers a low risk/high reward treatment option for MS patients. Additionally, HSCT and MSCT could work synergistically to further decrease adverse side effects and increase patient outcomes