As there is huge demand for liver transplantation but there are never enough organs and the procedure is not always successful, we can use bone marrow or umbilical cord blood stem cells to help to treat liver disease and reduce the need for liver transplantation. The discovery of adult tissue specific stem cells such as haemopiotic stem cells, which have the ability to transdifferentiate into other tissues, has generated much excitement among cell biologists and transplant clinicians. It opens new avenues for basic biological research by using stem cells from adults as an alternative to stem cells from embryos. It also carries important implications for the treatment of many liver, heart, and neurodegenerative diseases. Our work aimed at studying the outcome after transplantation of stem cells into patients with liver cirrhosis and to compare the results between differentiated and undifferentiated stem cells also to compare the results between splenic versus portal vein injection of stem cells. Patients and methods 20 patients with liver cirrhosis child B or C divided into two groups ; group 1 ( 10 patients received BMSC transplantation through splenic injection 5 of them injected with undifferentiated stem cells ,the other 5 with differentiated stem cells); group 2 ( 10 patients received BMSC transplantation through portal vein injection 5 of them injected with undifferentiated stem cells while the other 5 with differentiated stem cells ). Both groups undergo clinical evaluation by proper history taking, physical examination, routine laboratory investigations and abdominal ultrasonography ; Aspiration of bone marrow from iliac crest of all patients to obtain hematopoietic stem cells followed by in vitro culture to obtain the mesenchymal stem cells and addition of hepatocyte growth factor to differentiate the stem cells into differentiated type in 10 of them then transplantation of stem cells either through interasplenic or portal vein injection ; Follow up of patients for 6 months after transplantation with monitoring of liver enzymes, prothrombin time and concentration ; Serum albumin and clinical evaluation to evaluate the outcome. Results: after 6 months follow up, the result of present work shows that stem cell transplantation have a beneficial effect on synthetic function of the liver and possibly improve survival and quality of life of patients with end stage liver disease. Hepatocyte transplantation may not be able to reverse portal hypertension, or the development of HCC, but improvement in liver physiology and patient survival could be possible and could play a significant role in the management of patients with liver failure.