Intrauterine growth restriction (IUGR) has well-recognized perinatal and long term consequences. Because not all fetuses that are found to be small in utero have true growth restriction, the distinction of placental insufficiency from constitutional smallness has been one of the goals of fetal medicine over the last 20 years. Although intrauterine growth-restricted (IUGR) fetuses develop protective mechanisms, such as increased blood flow and oxygen uptake, they have an increased risk of developing signs of brain damage at birth. Our study was a prospective observational study that aimed to analyze the possible existence of differences in the volume of fetal intracranial structures between IUGR (symmetric and asymmetric) and appropriate-for-gestational age fetuses in relation to MCA Doppler to determine cases with brain sparing effect and whether there is corresponding change in brain volume in relation to MCA Doppler changes. In our study, 160 patients were included from those attending the Obstetrics and Gynecology department, fetal medicine unit at Kasr AL Aini hospital, Cairo University. We used VOCAL, which provides a semiautomatic delineation that frequently requires manual adjustments by the operator. VOCAL was selected instead of a multiplanar technique because this method requires less time to calculate volumes and has acceptable reproducibility. A technically successful measurement was obtained in all cases. Fetal brain volume data demonstrate a statistically significant linear increase of fetal brain volume relative to gestational age. Weekly increase in fetal brain volume is 20.51cm3 for IUGR and 22.53 cm3 for AGA. The fetal BV in IUGR is 296.366 cm3. In AGA group the fetal BV is 335.284 cm3.