UTI is one of the most common and most important infections to diagnose and properly manage especially in the pediatric age group. Chronic kidney hazards could develop if not well managed in time. The aim of the current study was to evaluate the risk factors and the organisms encountered in the development of recurrent UTIs. In this retrospective study, we collected the data of 126 patients following at nephrology clinic, Children hospital, Cairo University during the period Jan 2011-Dec 2012. The mean age of the studied group was 3.9 ± 3.7 years, the female : male ratio was 1.06:1, the main presenting symptoms were dysuria (16.7%) and fever (15.9%), the main pathology found were obstructive uropathy (23.3%), reflux nephropathy (22.1%), followed by structural anomalies of the urinary tract (20.9%). The main organisms found in their recurrent UTIs were E-coli (32.6%), Klebsiella (23.6%) and Pseudomonas (11.5%), they were mostly sensitive to Imipenem and Amikacin where E-coli was 62.2 % and 62.8% respectively, Klebsiella 79.6% and 66.4% respectively, and Pseudomonas 67.3% and 41.8% respectively sensitive to them. From the current study, we concluded that there have been increasing resistance trends to first-line antibiotics such as penicillins, augmentin and trimethoprim, and empirical antibiotic treatment in UTIs in children should relay on surveillance data on the epidemiology and emerging resistance patterns to common uropathogens.