Background: It was believed that Hepatitis B and Hepatitis D infection causes more severe liver injury than HBV alone. Recognition of this infection is very important because knowing the presence of both infections allows more accurate prognosis. Aim: To study the prevalence of delta infection among chronic HBV Egyptian patients and its impact on the virological and clinical status of patients with HBV/HDV infection and to perform genotyping with genetic sequence analysis of HDV.Methods: Prevalence of delta infection was evaluated using both HDV-RNA by PCR and anti HDV IgG. Genotypes and subtypes for both HBV and HDV were determined, routine biochemical, serological investigations and Transient Elastography were done. Liver biopsy was done whenever indicated. Results: A total of 121 treatment naive chronic HBV were included. Wild form of HBV-genotype D2 was reported with 78.5% HBeAg negative status. HDV was prevalent in 8.3% by anti HDV IgG and 9.9% using HDV-RNA by PCR. Wild HDV-genotype IIb was reported in 83.3%. HDV was more common in males in 4th decade. Presence of HBV/HDV infection had no impact on clinical or laboratory investigations with non-significant liver damage in HBV population. Delta patients had negative HBeAg in 90.9% with low or undetectable HBV viremia. Conclusion: Although HBV/HDV prevalence was expected to decline due to comprehensive vaccination programs, HDV is not uncommon. Wild HDV-genotype IIb was the most common and Delta infection was associated with negative HBeAg status with low HBV viremia.