Mesenchymal stem cells (MSCs) have generated a great deal of excitement and promise as a potential source of cells for cell-based therapeutic strategies. These data provide the clue of using MSCs in the current work in curing cisplatin-induced nephrotoxicity, the severest adverse effect of the well-known anticancer drug; cisplatin. Forty adult male albino rat were used in this study. MSCs of bone marrow origin were injected into the rat tail vein one day after a single dose of intraperitoneal injection of cisplatin. Four weeks later, the kidney was examined morohologically, histopathologically and ultra-structurally. Renal functions (urea, creatinine) as well as serum electrolytes levels (Na, K) were estimated. Cisplatin induced histopathological changes in rat kideny and impaired renal functions. MSCs ameliorated cisplatin-induced nephrotoxicity to a great extent as evidenced morphologically histologically, ultra-structurally and biochemically.