Revascularization of an acutely ischemic limb may lead to the development of a reperfusion syndrome, characterized by acidosis, hyperkalemia, myoglobinuria, and disseminated intravascular coagulation. We evaluated the components of the femoral venous efflux after reperfusion of an acutely ischemic limb in fifteen patients and compered the result with the components of the femoral venous efflux after reperfusion of an acutely ischemic limb in another fifteen patients as a control group.Our study shows that the duration of ischemia is directly related to the severity of systemic hyperkalemia, systemic acidosis and serum level of creatine phosphokinase. The more prolongation in the duration of acute ischemia the more severe degree of systemic acidosis and hyperkalaemia produced by the ischemic tissue.The levels of the postoperative serum potassium and serum CPK were lower in the study group than the control group, which shows that venous drainage prior to revascularization in late cases of acute lower limb ischemia may ameliorate the ischemia-reperfusion injury.