The present work demonstrated that the effect of sodium fluoride injection for three successive weeks produced variable histological changes in the liver of rats. These changes appeared as loss of hepatic architecture, pyknosis of the nuclei and extensive vacuolation of the hepatocytes. Widespread congestion and dilatation of the hepatic sinusoids and branches of the portal vein were noticed. Inflammatory cellular infiltration was also seen and was mainly in the periportal areas.