The aim of this study is to evaluate cerebral blood flow velocities, resistiveindex and pulsatility index in newborns with perinatal brain insult andcompare these values with healthy newborns to find out the most importantparameter which supports the diagnosis and its role in predicting theseverity of hypoxic-ischemic encephalopathy in asphyxiated term neonates.Methods: Peak systolic, end diastolic, time average velocity, resistive andpulsatility index were measured by color Doppler ultrasonography inmiddle and anterior cerebral arteries in 50 asphyxiated and 100 healthyterm infants in the first week of life. Differences between the asphyxiatedand control infants were subjected to statistical analysis.Results: Blood flow velocity parameters were significantly lower inasphyxiated infants compared to controls. Resistive index values werelower in measured vessels in asphyxial infants, and pulsatility index wassignificantly higher in asphyxiated infants compared with controls. Positiveand negative correlations were found between cerebral blood flow velocityparameters, resistive and pulsatility index and different stages of HIE.Conclusion: Doppler ultrasonography is considered an easy, less timeconsuming and non-invasive method which allows repeated, early and safeassessment modality to monitor the changes in cerebral hemodynamics thatcan be used for early diagnosis of HIE and help to distinguish the grades ofHIE