Hepatitis C accounts for a sizable proportion of cases of chronic liver disease, and cases of hepatocellular carcinoma and represents the most common indication for liver transplantation. Determining the presence or absence of significant fibrosis is essential in deciding protocol of management of patients infected with HCV, however liver biopsy is an invasive procedure with an occasional complications, for this reason, a noninvasive method for assessing hepatic fibrosis is needed. The study aimed to assess the performance of AST to Platelets Ratio Index (APRI) consisting of routine laboratory tests derived from AST and Platelets as one of the noninvasive markers in diagnosing the degree of liver fibrosis in 31 Egyptian patients with chronic geno type 4 HCV. The study revealed that there was a significant positive correlation between APRI and fibrosis stage in the studied patients. Using ROC curve for APRI in patients with different fibrosis stage (F1), (F2),(F3) and (F4) versus (F0), AUC was 1 and the best cutoff value was > 0.08 at which sensitivity was 100 % and specificity was 100 %. The study revealed that APRI was a reliable, simple and noninvasive test in predicting HCV related fibrosis compared to liver biopsy being the gold standard for diagnosis of hepatic fibrosis.