There are multiple causes of seizures presenting with many patterns and necessitating choice of anticonvulsant drugs. Seizures in neonatal period are common. They are caused by variety of conditions; ranging from benign; self limited illness to sever; life-threatening disorder. Multiple etiologies often co-exist in neonates and hence it is essential to rule out conditions as hypoglycemia, hypocalcaemia and hypomagnesaemia before initiating specific therapy. Treatment decisions should comprise different ways: treatment of the underlying cause. Phenobarbitone remains the first line drug in all types of seizures. Besides occasional seizures metabolic diseases remain exceptional. Nevertheless recognition of these conditions allows to establish the prognosis and to start immediately with an appropriate and specific medication. The presence of definite protocol for the diagnosis and management will improve the outcome. The aim of this review is to focus on the classification of neonatal "convulsions", to identify the underlying etiologies and the management. The study was conducted on 85 patients who were complaining of neonatal seizures admitted in Kasr Al-Aini neonatal intensive care unit during the period from January 2007 till March 2009.There were 57.6% males and 42.4% were females. Among this group of study 36.5% were delivered vaginally and 63.5% were delivered by CS, 40% of the studied patients were complaining of perinatal asphyxia and 60% were not complaining of perinatal asphyxia, 47.1% were discharged alive and 52.9% died. The mean gestational age for all patients was 36.2 ± 3.1 wk; weight at onset of convulsion for this group was 2.6 ± 0.9 kg with mean percentile 48.4 ± 30.9, weight on discharge was 2.6 ± 0.8 kg with mean percentile 40.3 ± 30.1. From this study we concluded that there is defect in our diagnosis of causes of neonatal seizures. There is defect in our investigations for diagnosis especially metabolic causes and radiological investigations. •There is abuse in using anticonvulsant drugs before diagnosis of etiology of seizure. •We have no definite protocol for control of convulsions.