Objectives : Evaluation of endometrial lesions (simple hyperplasia , atypical hyperplasia & carcinoma) according to their nuclear and glandular morphometric parameters , their D- score and according to their DNA ploidy which help in giving an accurate diagnosis. Study design : The study included 50 cases, 20 of them were simple hyperplasia, other 20 carcinoma and the 10 left cases were atypical hyperplasia. Cases were recruited and pathologically analyzed at Pathology Department Cairo University. Image analysis and DNA ploidy were done at National Research Centre at Pathology Department. Results : A significant difference in mean values of endometrial lesions morphometrical parameters including nuclear area p value=0.021[S], nuclear roundness p value =0.050[S] , all the glandular measurements include their distant , area, VPS were significant with p value =0.0433[S], 0.021[S], <0,0001[HS] respectively , D score p value< 0.001[|HS], DNA index p value=0.045[S], DNA diploid & aneuploid type also were highly significant with p value > 0.001. On the other hand long axis, short axis of the nuclea & nuclear form ellipsoid could not differentiate with p value =0.842[NS], 0.723[NS], 0.553 [NS] respectively. Conclusion : This study contributed to the endometrial lesions (simple hyperplasia, atypical hyperplasia & carcinoma) according to their morphometrical parameters and their DNA ploidy, allowing for the differentiation between them and to make close follow up for the high risk cases . Prediction the precancerous lesions by applying the D-score.