The primary therapeutic approach to PE is pharmacotherapy. Medical treatment of men with PE include a variety of approaches .Non-medical treatment are also licensed for use.Several studies talk about "off-label" effect of SSRIs in treating PE.In this study we compared effect of Escitalopram in treating PE with placebo; 100 patient involved in a double-blind randomized study.Group A (n= 50): This group received (10mg/d) Escitalopram for 4 weeks.Group B (n= 50): This group received placebo for the same period.