Background: It is well established that there is no better conduit than the native esophagus but there are some conditions in which the native esophagus cannot be preserved and needs to be replaced. This is a retrospective and prospective study for comparison between colon bypass and gastric tube performed on impassable corrosive esophageal stricture and esophageal atresia patients at the Pediatric Surgery Department at Cairo University Specialized Pediatric Hospital (CUSPH) between 2009 and 2013.Aim: This work is comparative study between gastric tube and colon bypass with or without gastrostomy in cases of post corrosive esophageal stricture and esophageal Atresia in children. The advantages, disadvantages, immediate and long term results of each technique are to be studied. Methods : The study comprises a total of fourty patients with corrosive esophageal stricture and esophageal atresia operated by the Cairo University Pediatric Surgery department between 2009 & 2013. Patients were randomly divided into two main groups; A & B. Group A patients was operated by the Colon bypass procedure, while Group B undergoes a gastric tube procedure. All these patients were subjected to full clinical study preoperatively.Results: Fourty patients with impassable Post corrosive esophageal stricture or esophageal atresia operated upon at the pediatric surgical department at Cairo University were randomly chosen and divided into 2 groups. Each group comprised 20 patients. The age distribution of the patients ranged between 6 months to 7 years for group A with mean age of 23.8 months (table 1). While for group B, the range was 5 months to 5 years with average 37.1 months. Operative success was considered in 70% of cases in Group A and in 80% of cases in Group B. These cases had smooth postoperative period and no long term complications on follow-up. The parents of these patients were satisfied with the outcome of the surgery. Total number of complicated cases were 6(30%) in Group A and 4 (20%) in Group B. Conclusion: this study confirms many difficulties in reconstructing the child’s esophagus. However, when the frequent early and late complications have been overcome, the long term prognosis of both gastric tube and colon bypass reconstruction seems quite good and both procedures have proven satisfactory surgical methods for esophageal replacement in children. These modalities restored gastrointestinal continuity with good long-term outcome and little impairment of quality of life of adult patients.