Exchange transfusion is not without risk; its complications include apnea, pulmonary hemorrhage, thrombocytopenia, coagulopathyies, hypoglycemia, hypocalcaemia, electrolyte imbalance, vasospasm, thrombosis, hypertension, arrhythmias, sepsis and necrotizing enterocolitis. In isoimmune hemolytic diseases of the newborn, antibodies (Anti-A, anti-B, anti- D) coated erythrocytes are mainly eliminated through, antibody dependant cellular cytotoxic effect by Fc receptor bearing cells of the reticuloendothelial system. In newborn infants, isoimmune hemolysis can be reduced or prevented and toxic bilirubin concentration can be avoided by means of reticuloendothelial Fc receptor blockage which means that the immunoglobulin act by occupying the Fc receptors of the the reticuloenothelial cells.