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The role of intravenous immunoglobulins in decreasing the need for exchange transfusion in neonatal hyperbilirubinemia

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Pediatrics

Advisors

Ebrahim, Nabil A., Ezz-El-Din, Zahraa M., Muhammad, Ayat A.

Authors

Esmaeil, Mirvat Esmaeil

Accessioned

2017-04-26 12:27:41

Available

2017-04-26 12:27:41

type

M.Sc. Thesis

Abstract

Exchange transfusion is not without risk; its complications include apnea, pulmonary hemorrhage, thrombocytopenia, coagulopathyies, hypoglycemia, hypocalcaemia, electrolyte imbalance, vasospasm, thrombosis, hypertension, arrhythmias, sepsis and necrotizing enterocolitis. In isoimmune hemolytic diseases of the newborn, antibodies (Anti-A, anti-B, anti- D) coated erythrocytes are mainly eliminated through, antibody dependant cellular cytotoxic effect by Fc receptor bearing cells of the reticuloendothelial system. In newborn infants, isoimmune hemolysis can be reduced or prevented and toxic bilirubin concentration can be avoided by means of reticuloendothelial Fc receptor blockage which means that the immunoglobulin act by occupying the Fc receptors of the the reticuloenothelial cells.

Issued

1 Jan 2009

DOI

http://dx.doi.org/10.21473/iknito-space/32403

Details

Type

Thesis

Created At

28 Jan 2023