This study aims at determination of Cathepsin-D (Cath-D) and Estrogen recoptor (ER) expression in normal, hyperplastic and malignant endometrial tissue through immunohistochemical analysis. The study included 85 patients suffering form abnormal uterine bleeding in addition to 15 women under infertility investigations as a control group. High Cath-D expression ( < 10% of cells ) was seen in 50% 70.6% 37.9% and 27.3% of proliferative, secretory, hyperplastic and malignant cells, respectively, cyclin D1 was overexpresed more than 60% of cells in atypical hyperplasia 42.85% & obviously cells group 69.44%, The mean percentagfe of Erialpha positive cells was 90.3% , 45.1% 77.3% and 33.6% in the proliferative, secretory, hyperplastic and malignant cells, respectively.