Thalassaemia syndromes are a heterogenous group of disorders resulting from the inability of the patients' red cells to synthesize an adequate amount of adult haemoglobin. The beta thalassaemias have emerged as a huge public health problem. Patients affected from homozygous beta-thalassemia have a high prevalence of chronic liver disease, mainly as a consequence of viral infections acquired through blood transfusion.The present study reports the prevalence of HCV, HBV and TTV infections among 50 multi-transfused thalassaemic children and 50 age and sex matched control subjects. HCV infection was detected in 44% of patients and 12% of control. HBV infection was present in 2% of patients and none of the control. Prevalence of TTV infection in patients was 60% compared to 48% in the control group. Prevalence of HCV infection increased with age and duration of blood transfusion. Infected subjects showed significant elevation of liver enzymes and higher percentages of hepatomegaly.Due to the successful immunization programme HBV infection had been greatly reduced.Prevalence of TTV infection, clinical features, laboratory data and annual transfusion numbers of TTV-positive and -negative patients were not observed to be statistically significant.