Background: Psoriasis is a chronic inflammatory skin disease. Genetic and immunologic mechanisms have been proposed in the aetiology of psoriasis. Coeliac disease (CD) can be defined as a chronic immune-mediated gluten-dependent enteropathy, resulting from an inappropriate T-cell-mediated immune response against ingested gluten in genetically predisposed people. Recent studies showed an association between CD and psoriasis and an improvement of skin lesions after 3–6 months GFD. Our study was undertaken to assess whether patients with psoriasis in Egypt have an increased prevalence of AGA and other coeliac disease antibodies or not and their possible role in the pathogenesis of psoriasis.Materials and Methods: This study comprised 41 patients of psoriasis vulgaris and 41 of healthy controls. All cases were subjected to complete history taking, clinical examination including psoriasis area and severity index (PASI) score. Patients and healthy controls were screened for serum IgA antibodies to gliadin (AGA) , IgA antitransglutaminase (TGA) as measured by ELISA and IgA anti¬bodies to endomysium (EMA), assessed by standard im¬munofluorescence with cryosection of monkey esopha¬gus.Results Our results showed significant difference between cases and controls as regards IgA (AGA) where as 34.1% of patients had IgA (AGA) positive as compared with controls (2.4%) with significant correlation between IgA (AGA) and duration and course of psoriasis and no significant difference between cases and controls as regards IgA (tTG) where as 34.1% of patients had IgA (tTG) positive as compared with controls (22%). Also we found no significant difference between cases and controls as regards IgA (EMA) where as (14.6%) of patients had IgA (EMA) positive as compared with controls (4.9%). Conclusion: Our study demonstrated significant increase in levels of CD antibodies in psoriatic patients in comparison to the controls so the serological evaluation for coeliac disease antibodies should be considered in psoriatic patients and early diagnosis of CD and administration of a gluten-free diet could lead to better management of such patients and might also result in decreased morbidity of such chronic skin disease.