Neonatal seizures are considered an acute manifestation of disturbance of neonatal brain and some of them can be considered as neonatal epilepsy. Study was conducted on 50 neonates presented with seizures during the first 28 days of life with different etiologies. Data were collected regarding maternal and peri-natal history, type of seizure, time of onset, time of cessation, and response to treatment. Electroencephalography (EEG) was done initially during the first month of life and repeated at the 6th month of life. Cranial ultrasound (CUS) findings were carried out to detect any anatomical or ischemic abnormality whenever required. All babies underwent biochemical testing for random blood sugar, serum calcium, and electrolytes. At the age of six months, patients in study group were followed up to identify the possible occurrence of adverse neurological outcome as regards to development of epilepsy, neurodevelopmental status via DenverII developmental screening test including motor and mental development and mortality to identify the possible risk factors that lead to these deficits.In this prospective study we found that; APGAR score at 5 minutes was an early predictor of patients' prognosis. Early control of neonatal seizures helps to improve the outcome, while prolonged time of cessation of seizures carry poor prognosis. We found that, hypoxic ischemic encephalopathy was the major cause of neonatal seizures and the myoclonic seizures carry the worst prognosis. Also, the commonest seizure type was subtle seizures, and the majority of them had good prognosis. We detected that, neonatal EEG is more accurate in predicting severe neurological disabilities while, combination between neuro-imaging and neonatal EEG allows the detection of mild and moderate brain lesions. We proved that, sequential EEG in neonatal seizures has more predictive value to estimate the outcomes of neurodevelopmental delay, epilepsy and neonatal death than single EEG.