Systemic lupus erythematosus (SLE) is a chronic inflammatory, autoimmune disease that affects mainly young women, who are generally less liable to atherosclerosis. The incidence of myocardial infarction is 5 times as high in patients with lupus as in the general population The aim of our study is to compare the incidence and extent of coronary artery calcification as measured by multidetector computed tomography in patients with systemic lupus erythematosus (SLE) and controls, and to identify variables associated with coronary calcification in patients with SLE.We studied 2 groups, group 1 included 30 patients with SLE and group 2 included 30 normal control subjects. Two groups were subjected to full history taking, clinical examination, laboratory investigations (CBC, urine analysis, serum urea, creatinine, Assessment of homocysteine, triglycerides, total cholesterol, high density and low density lipoproteins) and Multi Detector CT study of the coronaries. The patients were fulfilling American College of Rheumatology criteria for diagnosis of SLE and Control subjects didn’t meet the classification criteria for SLE. Both Patients and control subjects did not have history of cardiovascular disease (previous stroke, MI or Angina).In our study we found that coronary calcification was detected in patients with SLE by multi detector computed tomography and we found that the degree of calcification in patients with SLE was much higher in the older age group but was not statistically significant when compared to the younger age group, We also found that the level of total cholesterol in patients with SLE is positively correlated with calcium score with high statistical significance, and the level of triglyceride and LDL in patients with SLE were positively correlated with calcium score but not statistically significant. HDL is negatively correlated with calcium score with no statistical significance. We also found that the level of homocysteine in patients with SLE was higher than normal control subjects with highly statistically significance and homocysteine is positively correlated with calcium score with high statistical significance. We conclude that coronary artery calcification, as detected by electron-beam CT, is more common in patients with lupus than in general population and associated with risk factors as age, hyperlipidemia, renal affection and homocysteine.