The aim of our study was to reach a proper algorithm for accurate nodal staging and in turn lead to a better prognostic outcome. We found that PET/CT has shown significant improvement in radiologic staging of lung cancer however, it is not enough accurate to substitute mediastinoscopy. DWIBS is an outstanding tool to identify lymph nodes, irrespective of their histological composition so it can be complimentary to nanoparticle-enhanced MRI (SPIO). The histological type of lung cancer can guide the decision to perform invasive staging.