Aim of work: The objective is to study the role of PET/CT in the initial diagnosis and staging of patients with head and neck tumors, the overall clinical outcomes as well as in evaluation of treatment response and detection of recurrence. Comparing the PET/CT with the contrast enhanced CT.Setting: 69 patients with Head and Neck tumors had 83 PET/CT examinations.Results: FDG-PET/CT in head and neck cancer yielded additional diagnostic information in 51% of patients, with subsequent treatment plane change in (41.7%) of patients in the study. In our study PET/CT was significantly superior to CT concerning diagnostic accuracy in patients with head and neck cancer for assessment of treatment response and recurrent disease, with specificity, sensitivity, NPV, PPV, and accuracy of 27%, 74%,30%,71%,60% consecutively for CT and 91%,92%,83%,96%, and 92% consecutively for PET/CT.Conclusion: PET/CT is an imaging modality with high diagnostic performance in the assessment of head and neck cancer, and induced a significant change in further patient’s clinical management.