The first-line treatment for unresectable hepatic metastases from colorectal cancer is chemotherapy, which may be administered systemically or with a hepatic arterial infusion. Local response results of patients treated with drug eluting beads loaded with Irinotecan after 1 year were stable disease in 38%, complete resolution in 12%, while progressive disease in 23%. The results of our study show that it is a safe and effective way in the treatment of metastatic colorectal cancer.