Local injury to the endometrium using a pipell endometrial sampler doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization (Barash A et al, 2003).this study was confirmed by (Raziel et al, 2007). Local injury to endometriam of IVF patients in controlled ovarian hyperstimulation cycle may increase the incidence of embryo implantation. (Li R, Hao G, et al, 2009). Aim of the work : To review the effect of local injury to the endometrium on the outcome of IVF and embryo transfer. Patient and Method:A prospective controlled trial, a total 60 women in their first invitro fertilization (IVF)cycle were randomized .in 30 patient two small endometrial samples from anterior and posterior walls of the uterus were obtained with a pipelle endometrial sampler on the day before down regulation (group A) and in 30 patients no intervention was done(are used as control) (group B). The implantation will be calculated for both groups. The results will show whether the endometrial injury will increase implantation in IVF or not.