This study, the preemptive effect of a small dose of ketamine & magnesium sulphate on postoperative wound pain, intraoperative analgesic requirement & post-operative pethidine consumption in patients undergoing elective cesarean section was evaluated in a randomized control clinical trial, 60 women with American society of Anesthesiologist class I and II identification undergoing elective cesarean section were enrolled. Patients were divided into 3 groups 20 patients each. Ketamine group (K) received 0.3 mg/kg Ketamine in 20 mL. Magnesium group (M) received 30 mg/Kg Magnesium sulphate in 20 mL saline. Control group (C) received 20 mL of normal saline. All drugs were given in all groups 10 minutes before skin incision. Anesthesia was induced by a rapid-sequence induction with cricoid pressure is performed using 5% thiopental (5 mg/kg) was administered intravenously over 30 s, followed by succinylcholine 1.5 mg/kg. After tracheal intubation, the patients were ventilated with 100% oxygen. Isoflurane 0.8% is added, to maintain the anesthesia. Further neuromuscular block is maintained by using atracurium as needed. After the neonate are delivered 50 microgram fentanyl were given as bolus IV & further fentanyl were given guided by increase in heart rate & blood pressure by more than 20% of the base line. Heart rate & Blood pressure were recorded at base line, after intubation & 1 minute after skin incision. Intraoperative fentanyl requirement, post-operative pethidine requirements & pain visual analogue scale were recorded in the 1st 12 hours postoperatively.