Osteochondral lesions of the talus can cause functional impairment of the ankle joint, with inconvenience for patients and decrease their vital activity. Joint cartilage defect is a cause of pain and swelling in lower limb, regardless whether loaded, or at rest. Many methods are used to treat these injuries e.g. drilling, microfracture, autograft and allograft transplantation.Interest has focused on the treatment of vast and deep cartilage lesions with techniques such as, the use of autologous chondrocyte implantation (ACI) especially after emerging of the scaffold technique modification or matrix-induced autologous chondrocyte implantation (MACI).