The present work studies the effect of verapamil and ranitidine onindomethacin induced gastric ulcers in albino rats. The volume and pH ofgastric secretion was estimated and histopathological examination was done.It was found that indomethacin induced gastric ulcers weresignificantly reduced by verapamil. This decrease was duration dependent.There was no significant difference between this effect and that produced byranitidine.On the other hand, when both verapamil and ranitidine were usedtogether, it was found that there was a significant reduction in the meanulcer score and histopathological changes compared to that induced byverapamil or ranitidine alone. Gastric acidity and volume of gastric secretionshowed significant reduction in the same manner to mucosal changes.Also, indomethacin and ranitidine increased the gastric motilityinduced by acetylcholine. Whereas, verapamil decreased the gastric motility.When ranitidine and verapamil were used together there was a decrease ingastric motility in small doses and an increase in gastric motility in largedoses.