Thalssemia intermedia is clinical form of beta-thalassemia in which the clinical manifestation isless sever than thalassemia major. We studied 58patients who were diagnosed as thalassemiaintermedia and who are attending the hematologyclinic of Cairo University Children Hospital. Westudied their personal data, such as : age , sex,residence and consangunity, clinical criteria as ageat onest of the disease, complaint , presence ofpallor, juandice and hemolytic facies, requirementsto transfusion therapy as well as the initial diagnosticvalues such as CBC and HB electrophoresis