National Institutes of Health defined erectile dysfunction as a consistent inability to achieve or maintain an erection suffiecnt for satisfactory sexual activit . It has been speculated that neurovascular and hormonal effects of chronic HCV infection maycontribute to the pathogenesis of erectile dysfunction.AIM:The aim of this work is to assess the prevalence of ED in patients with chronic HCV infection .METHOD: The present study was carried out on 150patients with chronic HCV infection including 124 patients with chronic hepatitis and 26 patients with HCV-associated liver cirrhosis.All patients subjected to history taking ,general and local examination,liver profile,complete blood count,abdominal ultrasound,liver biopsy,FBS,TSH,AFP ,Arabic version of IIEF-5 and PPCD and those patients with ED score below 22.RESULT:We found the prevalence of ED in patients with Chronic HCV were (29.3%) and in patients with post hepatitis liver cirrhosis were( 92.3%) ,thereis significant correlation between albumin and ED in patients with liver cirrhosis.CONCLUSION: our study is the first and preliminary study in Egypt for determining ED prevalence in patients with chronic HCV infection by using both the Arabic version of IIEF-5 and the Pharmacopenile Doppler Ultrasonography (PPCD). The majority of patients with HCV-related liver cirrhosis proved to be suffering from ED and this may be attributed to the associated hypoalbuminemia.