Objective: To assess the health related quality of life (HRQOL) inpatients with knee osteoarthritis (OA) using the Nottingham HealthProfile (NHP) and to determine its relationships with conventionalclinical measures and self-reported disability.Patients and methods: Fifty patients with knee OA (17 males, 33females) with mean age 43.3 ± 8.55 years, and twenty five sex and agematchedcontrols were included in the study. HRQOL, disability and painwere assessed using NHP, Visual Analog Scale (VAS), physicalperformance was assessed using 15-meter test, ROM(flexion and degreeof incomplete extension) of the knee joint were measured usinggoniometer and the grade of osteoarthritis was scored using Kellgren –Lawrence radiological score (K-L score).Results: showed that all subgroups of the NHP (except social isolationsubgroup) revealed higher scores in the knee OA patients compared withcontrols (p < 0.001) .All subgroups of the NHP(except social isolationsubgroup) significantly correlated with age, VAS-rest, VAS-activity, 15-m walk test, the knee flexion, degree of incomplete extension of the kneeand K-L radiological (p < 0.001). There were statistically no significantcorrelations between the NHP physical mobility, pain, energy level, sleepand emotional reaction subgroup scores and body mass index (BMI)where p-value was 0.06, 0.11, 0.13, 0.07 and 0.14 respectively. Conclusion: The Nottingham Health Profile has been found to beextremely reliable for population with OA, as Patients reported manyproblems in the areas of physical mobility, pain, sleep, energy, andemotional reactions but no problems in the area of social isolation.