To study the association between IR and CHC infection in non diabetic patients and to find the relation between IR and the duration of hepatitis C infection, we studied 50 subjects, classified as group A including 15 patients with CHC<15 years duration, group B including 15 patients with CHC>15 years duration, group C including 20 normal controls. Fasting and pp serum insulin levels and calculation of IR using HOMA_IR were done to all subjects. We find that all markers of IR were higher in both groups of CHC than in controls and the differences were statistically significant.