The tongue is a fleshy highly mobile mass of muscular tissue attached to the floor of the mouth and covered with mucous membrane. Some lesions that appear on the tongue in the form of vesicles, spots, discoloration, erosions, fissures and others may indicate presence of dermatological diseases such as herpes simplex infection, lichen planus, psoriasis, dermatomyositis and others or may hide behind them, some of systemic diseases such as inflammatory bowel diseases, anemia, diabetes mellitus, allergy. So, careful examination of the tongue and also the entire buccal cavity with respect to the possible differential diagnoses of the existent lesion will help in accurate diagnosis of the condition giving rise to early and successful treatment helped by other methods of diagnosis such as histological examination, direct & indirect immunofluoresence and tumor markers.