The hepatitis C virus (HCV) is a major public health problem all over theworld with a global prevalence of 3%. It is responsible for 70% of cases withchronic hepatitis, the major cause of cirrhosis and the most common cause ofhepatocellular carcinoma. The current treatment of chronic hepatitis C is thecombination of interferon alpha and ribavirin with the sustained treatmentresponse range of 56-82%. Several extrahepatic manifestations have beenreported in the natural history of HCV infection. Up to 40-74% of patientsinfected with HCV might develop at least one extrahepatic manifestation during the course of their disease. Chronic HCV infection is associated with many extrahepatic manifestations in joints, muscles, neural, gastrointestinal tissues and skin. For many patients, cutaneous manifestations may be the only, the earliest, or the most apparent sign of the underlying infection. Therefore, it is important to understand the dermatologic manifestations of HCV infection.The aim of this study is to determine the prevalence of dermatologicmanifestations related to chronic HCV infection in Egypt.