43259

Adriamycin induced cardiotoxicity and thepossible protective role of Silymarin in adultmale albino rat : A light and electronmicroscopic study

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Anatomy

Advisors

Mitri, Helana L. , Abdel-Salam, Tareq A. , Ahmad, Eihab, A.

Authors

El-Sayed, Ramadhan Mussttafa

Accessioned

2017-07-12 06:41:50

Available

2017-07-12 06:41:50

type

M.Sc. Thesis

Abstract

Adriamycin is a potent anticancer agent, its clinical use isassociated with cardiotoxicity. The present study aimed to investigate thepossible protective role of the natural antioxidant silymarin onAdriamycin induced heart toxicity. The cardiotoxicity of Adriamycinwas manifested by elevateted cardiac enzymes (LDH & CPK) andincreased serum cholesterol and triglycerides. This toxicity wasassociated with severe histopathological changes in the form of highlyeosinophilic cytoplasm, degenerated myocardial fibers, interstitialoedema and mononuclear cellular infilteration. E/M examination of thecardiac muscle showed loss of cardiac myofilaments , swollen enlargedmitochondria and vaculation of the cytoplasm. Pretreatment withSilymarin ameliorated these pathological changes and decreased cardiacenzymes, serum cholesterol and TG levels.

Issued

1 Jan 2010

DOI

http://dx.doi.org/10.21473/iknito-space/37196

Details

Type

Thesis

Created At

28 Jan 2023