Combination of both basic and clinical reach advances during the last 15 years it has been found that beside the known role of AMH in regression of mullerian ducts in the male embryo during the fetal life, it has other important roles in the female after puberty including its role as a marker of ovarian reserve, marker of the extremes of ovarian response including both poor or response or exaggerated (OHSS) during COS in assisted reproduction techniques, as a maker of (POCS) and lastly as a marker (GCTs)