Preeclampsia (PE) is a pregnancy-specific multisystem disorder that ischaracterized by development of hypertension and proteinuria after 20 weeks of gestation, resolving by 6-12 weeks postpartum in a previous normotensive women(Sibai et al., 1987). It occurs in about 5% to 10% of all pregnancies and results in substantial maternal and neonatal morbidity and mortality (Cunningham et al., 2001).Recently, it was discovered that abnormal placentation may be due to deficiency in proangiogenic factors as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), and on the other side due to excess in circulating soluble form of fms-like tyrosine kinase-1 (sFlt-1). (Redman CW et al., 2003) PlGF and VEGF are two related protein members of the endothelial growth factor family that are likely responsible for normal trophoblast proliferation,migration and invasion (Ziche et al., 1997) ), and low levels of VEGF and PlGF or antagonists to VEGF and PlGF are plausible mediators of preeclampsia (Pascoal et al., 1998).