Cranial ultrasound was carried out on sixty full term neonates with variable congenital heart diseases who were referred to the cardiology clinic, Cairo University Children’s Hospital. Sixty healthy full term infants referred for follow up and born without antenatal or postnatal complications constituted the control group. Twenty-four (40%) of the sixty infants in the study showed cranial ultrasound abnormalities compared to four (7%) of the sixty infants in the control group (p <0.001).Ventricular and/or subarachnoid widening (8 cases, 13%), and lenticulostriate vasculopathy (8 cases, 13%), were the most frequent lesions. Three patients (5%) had signs of acute ischemic changes: 2 (3%) infarctions and 1 (2%) cerebral oedema. One patient (2%) had calcifications in the basal nuclei and one patient (2%) had agenesis of the cerebellar vermis. Conclusion:The high incidence of cranial ultrasound abnormalities in infants with congenital heart disease emphasizes the importance of cranial ultrasound examination and long-term neurodevelopmental follow-up in all infants with congenital heart disease.