Worldwide road traffic injuries cause more than 1.2 million deaths every year, and are the leading cause of death among those aged 15-44 years, Unfortunately Egypt has got one of the highest world's road accidents rate and the problem is growing. Objectives: This work aimed to determine different types of injuries and, the prognosis and outcome of the injured cases. Patients and Methods: It retrospectively overviewed 200 cases of road traffic accidents in Egypt examined at the Emergency Department, in Kasr Al-Aini Hospitals, through the year 2010 regarding their demographic data, different injuries, outcome and recording different types of vehicles involved in the accidents where any injuries on the road without involvement of a vehicle were excluded from the study. Results: most of the road traffic accidents (RTAs) occurred in Giza. The highest number of RTA victims were between >18 to 44 years, which represent (45.5%) of cases and males represented (88%) of the total cases. Most of road traffic accidents occurred during the morning and early afternoon (8 a.m.: 8 p.m.) which represented (48%) of cases. Cars represented (71%) of vehicles which were involved in the accidents, most cases of (RTAs)suffered from head and neck injuries (62.5%) and the lowest number of RTA victims suffered from spinal injuries (2 cases) (1%). The highest percent of cases were recovered (66%), while the mortality percent was 17.5% with 29 males and 6 female. The highest number of cases was not working (37.5%) and the number of children was 18 cases (9%) with the youngest was 1.5 years and the oldest was 18 years old. Conclusion: RTAs constitute a major public health problem and it is considered the leading cause of accidental injury under the age of forty which is the most active section in our country and in the whole world. Recommendation: Fulfilling the recommended data collection sheet will give very valuable information about road traffic accidents to find solutions which are applicable to our country.