The hepatitis C virus (HCV) epidemic in Egypt is unique in the world asthere are many publications suggest that over 15% of the people in Egyptare infected ,this is ten times greater than in any other country in theworld.Aim: To test whether Syndecan-1 and laminin could serve as noninvasivemarkers for detection of liver fibrosis in patients with chronichepatitis C and thereby reduce the need for liver biopsy. Methods:Estimation of Syndecan-1 and laminin in plasma by ELISA were done on50 subjects ( 20 normal healthy persons and 30 chronic hepatitis Cpatients). Results: The mean levels of plasma syndecan-1 and lamininwere significantly higher in group II (chronic HCV patients) whencompared to group I (control subjects ).Conclusion: Plasma Syndican-1 and laminin could serve as non-invasivemarkers for detection of liver fibrosis in patients with chronic hepatitisC .