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Impact of hepatitis c virological load and bilharzial antibodies on rapid virological response

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Internal Medicine

Advisors

El-Zanati, Taher , Fouda Ayman

Authors

Abou-Sheaishaa, Bahaa Muhammad

Accessioned

2017-07-12 06:40:15

Available

2017-07-12 06:40:15

type

M.Sc. Thesis

Abstract

Concurrent HCV-genotype 4 infection and schistosomiasis result in a much more severe liver disease however the response to HCV treatment is conflicting. A low baseline viral load (<600,000–800,000 IU/ ml or less) was shown to be an independent predictor of SVR regardless of genotype in numerous studies. Aim of the work: To determine if HCV viral load and anti schistosomal antibodies have an effect on RVR in patients with chronic hepatitis C virus genotype 4. Patients and methods: This study was carried out on 136 patients with chronic hepatitis C. The patients were classified into 4 groups according to HCV viral load (cut- off 600,000 IU/ml) and presence or absence of anti schistosomal antibodies (significant if ≥1/160). All the patients treated with pegylated interferon plus weight based ribavirin and tested for HCV RNA by real time PCR after 4 weeks of treatment to detect RVR and compare the results between the 4 groups to detect the impact of HCV viral load and anti bilharzial antibodies on the response to treatment.Results: Our study showed that HCV viral load was the only significant factor associated with RVR. There is no significant difference between patients with bilharzial antibodies positive and patients with bilharzial antibodies negative regarding the impact on RVR. Conclusion: Patients with low HCV viral load have a better response than those with high viral load regarding RVR with no any significant effect regarding the presence of bilharzial antibodies on this response.

Issued

1 Jan 2011

DOI

http://dx.doi.org/10.21473/iknito-space/35225

Details

Type

Thesis

Created At

28 Jan 2023