This study included 55 patients, 30 patients with ascites of local peritoneal cause and 25 patients with bowel lesions in which endoscopic biopsies were negative or endoscopy was not feasible. All patients were subjected to: history, clinical examination, laboratory investigations and ultrasound. Ultrasound guided fine-needle aspiration cytology of ascetic fluid were done in patients with ascites of peritoneal cause and 27 patients underwent core biopsies. Ultrasound guided core biopsies were done in all patients with bowel lesions. In the first group, ultrasound guided FNAC gave positive results in 7 patients (23.33%) and core biopsies were positive in 24 patients (88.89%). Diagnostic accuracy in patients with bowel lesions was 92 %.