The role of inflammation and inflammatory markers in the pathogenesis of stroke and atherosclerosis is increasingly appreciated. This study included 30 ischemic stroke patients and 30 healthy controls. Patients were evaluated clinically and by outcome scales (BI & mRS). All subject undergone laboratory levels for sICAM & sVCAM and U/S imaging (Doppler for ABI, Extra- and Trans cranial color coded duplex). Levels of sICAM & sVCAM were higher in the patient group and correlated with carotid atherosclerotic plaques and stenosis. We concluded that elevations in sICAM reflect overt atherosclerosis while sVCAM is suggestive of advanced degree of atherosclerotic disease.