Objectives and aim of the work : The specific aim was to study the level of vitamin D in systemic sclerosis patients and to study its effect on bone density evaluated by DEXA.Patients and Methods: 25 patients with systemic sclerosis and 25 healthy persons who served as control participated in this study. All patients and controls were subjected to full history taking, clinical examination, laboratory investigations (including serum 25 (OH) vitamin D) and radiological evaluation including DEXA. Results: the frequency of vitamin D deficiency was highly statistically significant in systemic sclerosis patients (60%) when compared to controls (20%) (p value=0.018). As regards the different positive DEXA findings,there was a highly significant difference between DEXA findings in SSc patients compared to controls (p value=0.000) (as it was found that 10/25 patients (40%) had osteoporosis, 9/25 patients (36%) had osteopenia and 6/25 patients (24%) had normal bone density while in controls there were only 2/25 persons (8%) who had osteopenia, the rest were normal.Conculsion: systemic sclerosis patients had significantly higher vitamin D defenciecy when compared to control. A highly significant difference was found concerning DEXA findings of systemic sclerosis patients when compared to control.Recommendations: We recommend that vitamin D level in all patients with autoimmune diseases especially systemic sclerosis should be evaluated, vitamin D and calcium supplementation should be given to systemic sclerosis patients.