Prostate cancer is one of the most important cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility, environmental exposure in its largest sense and differences in health care and cancer registration (or a combination of these). The marked increase in detection of prostate cancer occurred due to the development of tumor markers of prostate mainly prostate specific antigen (PSA).The sensitivity of PSA is impressive but low specificity result in increase the number of unnecessary biopsies. The rise in the number of potential prostate markers may overcome the weakness in the use of PSA alone as a marker for cancer prostate.